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Article

Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania.

Nature communications - 11 May 2017

Parks Tom, Mirabel Mariana M, Kado Joseph, Auckland Kathryn, Nowak Jaroslaw, Rautanen Anna, Mentzer Alexander J, Marijon Eloi, Jouven Xavier, Perman Mai Ling, Cua Tuliana, Kauwe John K, Allen John B, Taylor Henry, Robson Kathryn J, Deane Charlotte M, Steer Andrew C, Hill Adrian V S

Abstract excerpt

The indigenous populations of the South Pacific experience a high burden of rheumatic heart disease (RHD). Here we report a genome-wide association study (GWAS) of RHD susceptibility in 2,852 individuals recruited in eight Oceanian countries. Stratifying by ancestry, we analysed genotyped and imputed variants in Melanesians (607 cases and 1,229 controls) before follow-up of suggestive loci in three further...

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Identifiers

PMID: 28492228
DOI: 10.1038/ncomms14946
PMCID: PMC5437274

Genes

RHD
IGH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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