Article
Rare variants in PLXNA4 and Parkinson's disease.
PloS one - 1 Jan 2013
Schulte Eva C, Stahl Immanuel, Czamara Darina, Ellwanger Daniel C, Eck Sebastian, Graf Elisabeth, Mollenhauer Brit, Zimprich Alexander, Lichtner Peter, Haubenberger Dietrich, Pirker Walter, Brücke Thomas, Bereznai Benjamin, Molnar Maria J, Peters Annette, Gieger Christian, Müller-Myhsok Bertram, Trenkwalder Claudia, Winkelmann Juliane
Abstract excerpt
Approximately 20% of individuals with Parkinson's disease (PD) report a positive family history. Yet, a large portion of causal and disease-modifying variants is still unknown. We used exome sequencing in two affected individuals from a family with late-onset familial PD followed by frequency assessment in 975 PD cases and 1014 ethnically-matched controls and linkage analysis to identify potentially causal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.