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Article

A3D database: structure-based predictions of protein aggregation for the human proteome.

Bioinformatics (Oxford, England) - 26 May 2022

Badaczewska-Dawid Aleksandra E, Garcia-Pardo Javier, Kuriata Aleksander, Pujols Jordi, Ventura Salvador, Kmiecik Sebastian

Abstract excerpt

SUMMARY: Protein aggregation is associated with many human disorders and constitutes a major bottleneck for producing therapeutic proteins. Our knowledge of the human protein structures repertoire has dramatically increased with the recent development of the AlphaFold (AF) deep-learning method. This structural information can be used to understand better protein aggregation properties and the rational design of...

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PMID: 35445695
DOI: 10.1093/bioinformatics/btac215
PMCID: PMC9746890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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