Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection

Abstract excerpt

MAIT cells, defined as CD161++TCR iVα7.2+ T cells, play an important role in the innate defence against bacterial infections and their functionality is impaired in chronic viral infections. Here, we investigated the frequency and functional role of MAIT cells in chronic HBV infection. The peripheral CD3+CD161++TCR iVα7.2+ MAIT cells in chronic HBV-infected patients and healthy controls were phenotypically...

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