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Article

Genome‑wide DNA hypomethylation drives a more invasive pancreatic cancer phenotype and has predictive occult distant metastasis and prognosis potential.

International journal of oncology - 1 Jun 2022

Endo Yuhei, Suzuki Koichi, Kimura Yasuaki, Tamaki Sawako, Aizawa Hidetoshi, Abe Iku, Watanabe Fumiaki, Kato Takaharu, Saito Masaaki, Futsuhara Kazushige, Noda Hiroshi, Konishi Fumio, Rikiyama Toshiki

Abstract excerpt

Genome‑wide DNA hypomethylation is the most common molecular feature in human cancers associated with chromosomal instability (CIN), which is involved in the mechanisms that regulate pancreatic cancer (PC) metastasis. It was investigated whether genome‑wide DNA hypomethylation affects the phenotype in PC via CIN in vitro, and its significance on the biological behavior of PC was verified. The relative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35419613
DOI: 10.3892/ijo.2022.5351
PMCID: PMC9015190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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