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DNA Hypomethylation in Pancreatic Cancer Tissues Before Treatment, Defined by KRAS -mutated Circulating Tumor DNA, is Associated With Poor Prognosis.

Pancreas - 1 Aug 2026

Watanabe Fumiaki, Suzuki Koichi, Hasebe Ryuji, Mizusawa Yuki, Aizawa Hidetoshi, Abe Iku, Endo Yuhei, Ichida Kosuke, Inoue Koetsu, Noda Hiroshi, Rikiyama Toshiki

Abstract excerpt

OBJECTIVES: Aberrant hypomethylation of long interspersed nucleotide element-1 (LINE-1) and satellite alpha (SATa) in pancreatic cancer cells increases malignant potential. In addition, circulating tumor DNA (ctDNA) is likely to be associated with micrometastasis and appears more frequently in advanced pancreatic ductal adenocarcinoma (PDAC) patients. In this study, we elucidated the relationship between these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42224085
DOI: 10.1097/MPA.0000000000002650

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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