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Article

Prognostic Relevance of Aberrant DNA Methylation in G1 and G2 Pancreatic Neuroendocrine Tumors

1 Jan 2014

Abstract excerpt

BACKGROUND/AIMS: The occurrence and clinical relevance of DNA hypermethylation and global hypomethylation in pancreatic neuroendocrine tumours (PanNETs) are still unknown. We evaluated the frequency of both epigenetic alterations in PanNETs to assess the relationship between methylation profiles and chromosomal instability, tumour phenotypes and prognosis. METHODS: In a well-characterized series of 56 sporadic G1...

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PMID: 25011998
DOI: 10.1159/000365449

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