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Article

Ficolin-2 Lectin Complement Pathway Mediates Capsule-Specific Innate Immunity Against Invasive Pneumococcal Disease

28 Mar 2022

Abstract excerpt

Reports conflict regarding which lectin-microbial ligand interactions elicit a protective response from the lectin pathway (LP) of complement. Using fluorescent microscopy, we demonstrate the human lectin ficolin-2 binds to Streptococcus pneumoniae serotype 11A capsule polysaccharide dependent on the O-acetyltransferase gene wcjE. This triggers complement deposition and promotes opsonophagocytosis of encapsulated...

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Identifiers

PMID: 35418983
DOI: 10.3389/fimmu.2022.841062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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