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Article

Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2012

Endo Yuichi, Takahashi Minoru, Iwaki Daisuke, Ishida Yumi, Nakazawa Naomi, Kodama Toshihisa, Matsuzaka Tomohiro, Kanno Kazuko, Liu Yu, Tsuchiya Kohsuke, Kawamura Ikuo, Ikawa Masahito, Waguri Satoshi, Wada Ikuo, Matsushita Misao, Schwaeble Wilhelm J, Fujita Teizo

Abstract excerpt

Mannose-binding lectin (MBL) and ficolin are complexed with MBL-associated serine proteases, key enzymes of complement activation via the lectin pathway, and act as soluble pattern recognition molecules in the innate immune system. Although numerous reports have revealed the importance of MBL in infectious diseases and autoimmune disorders, the role of ficolin is still unclear. To define the specific role of...

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Identifiers

PMID: 23150716
DOI: 10.4049/jimmunol.1200836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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