Article
Targeting the EGFR-ERK axis using the compatible solute ectoine to stabilize CFTR mutant F508del.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2022
Wellmerling Jack, Rayner Rachael E, Chang Sheng-Wei, Kairis Elizabeth L, Kim Sun Hee, Sharma Amit, Boyaka Prosper N, Cormet-Boyaka Estelle
Abstract excerpt
Mutations in the CFTR gene lead to cystic fibrosis, a genetic disease associated with chronic infection and inflammation and ultimately respiratory failure. The most common CF-causing mutation is F508del and CFTR modulators (correctors and potentiators) are being developed to rescue its trafficking and activity defects. However, there are currently no modulators that stabilize the rescued membrane F508del-CFTR...
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