Article

Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells

2024-03-04

Abstract excerpt

<h4>Background</h4> Cystic Fibrosis causing mutations in the gene CFTR , reduce the activity of the CFTR channel protein, and leads to mucus aggregation, airway obstruction and poor lung function. A role for CFTR in the pathogenesis of other muco-obstructive airway diseases such as Chronic Obstructive Pulmonary Disease (COPD) has been well established. The CFTR modulatory compound, Ivacaftor (VX-770), potentiate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4b6b3122-dc4f-5ceb-ad71-f108d1184f83
DOI: 10.1101/2024.03.01.582742

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cellsDOI 10.1101/2024.03.01.582742Read

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770.Semantic proximity Read

A small molecule CFTR potentiator restores ATP-dependent channel gating to the cystic fibrosis mutant G551D-CFTR.Semantic proximity Read

Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.Semantic proximity Read

Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosisSemantic proximity Read

A CFTR potentiator in patients with cystic fibrosis and the G551D mutation.Semantic proximity Read

Modulation of cAMP metabolism for CFTR potentiation in human airway epithelial cellsSemantic proximity Read

Potentiator synergy in rectal organoids carrying S1251N, G551D, or F508del CFTR mutations.Semantic proximity Read

Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation.Semantic proximity Read

Acute administration of ivacaftor to people with cystic fibrosis and a G551D-CFTR mutation reveals smooth muscle abnormalitiesSemantic proximity Read

Mutation-specific downregulation of CFTR2 variants by gating potentiators.Semantic proximity Read

Potentiators (specific therapies for class III and IV mutations) for cystic fibrosis.Semantic proximity Read

Ivacaftor potentiation of multiple CFTR channels with gating mutations.Semantic proximity Read