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Article

A small molecule that binds to an ATPase domain of Hsc70 promotes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator.

Journal of the American Chemical Society - 21 Dec 2011

Cho Hyungseoph J, Gee Heon Yung, Baek Kyung-Hwa, Ko Sung-Kyun, Park Jong-Moon, Lee Hookeun, Kim Nam-Doo, Lee Min Goo, Shin Injae

Abstract excerpt

Cystic fibrosis transmembrane conductance regulator (CFTR) is a cell-surface anion channel that permeates chloride and bicarbonate ions. The most frequent mutation of CFTR that causes cystic fibrosis is the deletion of phenylalanine at position 508 (ΔF508), which leads to defects in protein folding and cellular trafficking to the plasma membrane. The lack of the cell-surface CFTR results in a reduction in the...

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Identifiers

PMID: 22074182
DOI: 10.1021/ja206762p

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A small molecule that binds to an ATPase domain of Hsc70 promotes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator.PMID 22074182Read ↗

Targeting ubiquitination machinery in cystic fibrosis: Where do we stand?Semantic proximity Read ↗

Matrine modulates HSC70 levels and rescues ΔF508-CFTR.Semantic proximity Read ↗

The multiple ubiquitination mechanisms in CFTR peripheral quality control.Semantic proximity Read ↗

Regulation of CFTR Biogenesis by the Proteostatic Network and Pharmacological Modulators.Semantic proximity Read ↗

Adapting Proteostasis and Autophagy for Controlling the Pathogenesis of Cystic Fibrosis Lung DiseaseSemantic proximity Read ↗

Targeting the E1 ubiquitin-activating enzyme (UBA1) improves elexacaftor/tezacaftor/ivacaftor efficacy towards F508del and rare misfolded CFTR mutants.Semantic proximity Read ↗

Phosphorylation of the Chaperone-Like HspB5 Rescues Trafficking and Function of F508del-CFTR.Semantic proximity Read ↗

Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epitheliaSemantic proximity Read ↗

Selective Binding of HSC70 and its Co-Chaperones to Structural Hotspots on CFTRSemantic proximity Read ↗

Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of DeltaF508-CFTR.Semantic proximity Read ↗

KDM2A and KDM3B as Potential Targets for the Rescue of F508del-CFTR.Semantic proximity Read ↗

CFTR chloride channel in the apical compartments: spatiotemporal coupling to its interacting partnersSemantic proximity Read ↗

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