Article

Clinical Response to a PARP Inhibitor and Chemotherapy in a Child with BARD1-Mutated Refractory Neuroblastoma: A Case Report

2023-08-16

Abstract excerpt

<title>Abstract</title> <p>Despite advances in the treatment of high-risk neuroblastoma, approximately half of these patients die from the disease. Targeted therapy based on synthetic lethality associated with homologous recombination deficiency (HRD) caused by germline mutations in homologous recombination repair genes has shown great efficacy in several adult solid tumors. Here we report the first successful tr...

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Literature Corpus work: 2b2a3ecb-6f13-52f6-a176-b318794953e1
DOI: 10.21203/rs.3.rs-3250117/v1

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