Article
Tumor Necrosis Factor-α Induces a Preeclamptic-like Phenotype in Placental Villi via Sphingosine Kinase 1 Activation.
International journal of molecular sciences - 29 Mar 2022
Fakhr Yuliya, Koshti Saloni, Habibyan Yasaman Bahojb, Webster Kirsten, Hemmings Denise G
Abstract excerpt
Preeclampsia (PE) involves inadequate placental function. This can occur due to elevated pro-inflammatory tumor necrosis factor-α (TNF-α). In other tissues, TNF-α signals via sphingosine kinase 1 (SphK1). SphK1 hinders syncytial formation. Whether this occurs downstream of TNF-α signaling is unclear. We hypothesized that placental SphK1 levels are higher in PE and elevated TNF-α decreases syncytial function,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.