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Article

Loss of polarity regulators initiates gasdermin-E-mediated pyroptosis in syncytiotrophoblasts

19 Jul 2023

Abstract excerpt

The syncytiotrophoblast is a human epithelial cell that is bathed in maternal blood on the maternal-facing surface of the human placenta. It therefore acts as a barrier and exchange interface between the mother and fetus. Syncytiotrophoblast dysfunction is a feature of pregnancy pathologies, like preeclampsia. Dysfunctional syncytiotrophoblasts display a loss of microvilli, which is a marker of aberrant...

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PMID: 37468163
DOI: 10.26508/lsa.202301946

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