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Antiferroptotic Drugs Reduce sFlt-1 Release and Placenta Damage in Preeclampsia

19 Aug 2025

Abstract excerpt

BACKGROUND: Preeclampsia is characterized by hypertension, proteinuria, and elevated antiangiogenic sFlt-1 (soluble fms-like tyrosine kinase-1) levels. Despite extensive research, mechanisms underlying sFlt-1 dysregulation remain unclear. This hypothesis-testing study investigated whether ferroptosis, a lipid peroxidation-driven cell death mechanism, contributes to preeclamptic placental pathogenesis and sFlt-1...

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PMID: 40827397
DOI: 10.1161/hypertensionaha.125.25003

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