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On the origins and fate of chromosomal abnormalities in human preimplantation embryos: an unsolved riddle

1 Apr 2022

Abstract excerpt

About 8 out of 10 human embryos obtained in vitro harbour chromosomal abnormalities of either meiotic or mitotic origin. Abnormalities of mitotic origin lead to chromosomal mosaicism, a phenomenon that has sparked much debate lately as it confounds results obtained through preimplantation genetic testing for aneuploidy (PGT-A). PGT-A in itself is still highly debated, not only on the modalities of its execution...

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PMID: 35404421
DOI: 10.1093/molehr/gaac011

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