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Article

Cytoplasmic superoxide causes bone fragility owing to low-turnover osteoporosis and impaired collagen cross-linking.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2011

Nojiri Hidetoshi, Saita Yoshitomo, Morikawa Daichi, Kobayashi Keiji, Tsuda Chizuru, Miyazaki Tsuyoshi, Saito Mitsuru, Marumo Keishi, Yonezawa Ikuho, Kaneko Kazuo, Shirasawa Takuji, Shimizu Takahiko

Abstract excerpt

The aging process correlates with the accumulation of cellular and tissue damage caused by oxidative stress. Although previous studies have suggested that oxidative stress plays a pathologic role in the development of bone fragility, little direct evidence has been found. In order to investigate the pathologic significance of oxidative stress in bones, we analyzed the bone tissue of mice deficient in cytoplasmic...

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PMID: 22025246
DOI: 10.1002/jbmr.489

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SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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