HRDetect in Tubo-ovarian Carcinoma: Stratification and Therapeutic Implications.

doi:10.1158/1078-0432.CCR-25-1629

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Article

HRDetect in Tubo-ovarian Carcinoma: Stratification and Therapeutic Implications.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2026

Banda Kalyan, Davies Helen R, Kumar Yogesh, Memari Yasin, Degasperi Andrea, Radke Marc, Rodriguez Isabel, Gooley Ted A, Katz Ronit, Menghi Francesca, Harding Thomas, Lin Kevin, Liu Edison T, Nik-Zainal Serena, Swisher Elizabeth M

Abstract excerpt

PURPOSE: To evaluate HRDetect, a mutational signature-based algorithm, for prognostic utility in tubo-ovarian carcinoma and to determine if whole-genome sequencing (WGS) with rearrangement signature (RS) analysis can refine genomic classification beyond the traditional homologous recombination-deficient versus homologous recombination-proficient framework. EXPERIMENTAL DESIGN: WGS was performed on matched...

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Topics

Humans
Female
Prognosis
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Whole Genome Sequencing

Poly(ADP-ribose) Polymerase Inhibitors

Ovarian Neoplasms

Aged

Biomarkers, Tumor

Adult

Fallopian Tube Neoplasms

Indoles

Homologous Recombination

Source

Open in PubMed Open full text

Identifiers

PMID: 42201779
DOI: 10.1158/1078-0432.CCR-25-1629
PMCID: PMC13367564

Genes

BRCA1
RS1

Provenance

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