Article

HRDetect in Ovarian Carcinoma: Stratification and Therapeutic Implications

2025-03-06

Abstract excerpt

In this study, we show that comprehensive DNA profiling using whole genome sequencing (WGS) can offer novel insights into ovarian carcinoma (OC). First, using WGS of 185 OC with HRDetect profiling, a mutational signature-based algorithm for homologous recombination repair deficiency (HRD), we found that patients with HRDetect-high OC had significantly better overall survival, with a median of 6.2 years compared to...

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Literature Corpus work: 3653da18-2d57-5d72-97b2-283bde1f69ef
DOI: 10.1101/2025.03.03.25323026

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