Article
Molecular Characterization of Metanephric Adenoma, Epithelial Wilms Tumor, and Overlap Lesions: An Integrated Whole-exome and Transcriptome Sequencing Analysis.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Apr 2022
Pan Chin-Chen, Tseng Chih-En, Kuroda Naoto, Yano Mitsutake, Yasuda Masanori, Nagashima Yoji, Yeh Yi-Chen, Wang Yu-Chao, Chang Yen-Hwa, Epstein Jonathan I
Abstract excerpt
Metanephric adenoma (MA) and Wilms tumor (WT) represent 2 prototypes of primary renal neoplasms closely resembling embryonal renal tubules. Tumors with overlapping features may occur, requiring differential diagnoses between the 2. Evidence of divergent oncogenic pathways has been reported, suggesting that MA is driven by BRAF mutation while most WT is of the BRAF wild-type. We collected 4 MA cases, 3 cases of...
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