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Article

Molecular characterisation of metanephric adenomas beyond BRAF: genetic evidence for potential malignant evolution.

Histopathology - 1 Jun 2020

Chan Emily, Stohr Bradley A, Croom Nicole A, Cho Soo-Jin, Garg Karuna, Troxell Megan L, Higgins John P, Bean Gregory R

Abstract excerpt

AIMS: Metanephric adenomas (MAs) are conventionally regarded as rare renal tumours with indolent behaviour; limited case reports have described MAs with aggressive features. Conventional MAs harbour hotspot BRAF V600E mutations. A BRAF V600E senescence pathway, mediated by cyclin-dependent kinase inhibitor 2A (CDKN2A)/p16, has been proposed to confer MA benignity. Aside from BRAF, the molecular landscape in both...

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PMID: 32064677
DOI: 10.1111/his.14094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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