Article
Adult Wilms Tumor: Genetic Evidence of Origin of a Subset of Cases From Metanephric Adenoma.
The American journal of surgical pathology - 1 Jul 2022
Argani Pedram, Tickoo Satish K, Matoso Andres, Pratilas Christine A, Mehra Rohit, Tretiakova Maria, Sibony Mathilde, Meeker Alan K, Lin Ming-Tseh, Reuter Victor E, Epstein Jonathan I, Gagan Jeffrey, Palsgrove Doreen N
Abstract excerpt
The genetics of nephroblastoma (Wilms tumor) occurring in adults is largely unknown, as studies have largely been limited to isolated case reports. We, therefore, studied 14 adult Wilms tumors for genetic alterations, using expanded targeted sequencing on 11 cases. The patients ranged from 17 to 46 years of age (mean and median, 31 y), and there were 8 males and 6 females. Five Wilms tumors harbored BRAF V600E...
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