Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Physical confinement in alginate cryogels determines macrophage polarization to a M2 phenotype by regulating a STAT-related mRNA transcription pathway.

Biomaterials science - 4 May 2022

Liu Zhen-Zhen, Xu Nian-Yuan, Wang Mei-Ling, Tang Rui-Zhi, Liu Xi-Qiu

Abstract excerpt

The immunologic response is considered to play a pivotal role in the application of biomaterial implants, and intrinsic properties of biomaterials can significantly modulate the anti-inflammatory effects. However, how physical confinement influences M2 polarization of macrophages and the relevant mechanisms have not been clearly elucidated. In this study, pore size and porosity in cryogels can be mediated by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alginates
Share to Anti-Inflammatory Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages

Share to Phenotype

Share to RNA, Messenger

Source

Identifiers

PMID: 35373788
DOI: 10.1039/d1bm01719e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Physical confinement in alginate cryogels determines macrophage polarization to a M2 phenotype by regulating a STAT-related mRNA transcription pathway.PMID 35373788Read ↗

Primary human macrophages are polarized towards pro-inflammatory phenotypes in alginate hydrogelsSemantic proximity Read ↗

Distinct matrix viscoelasticity in bone fracture hematoma steers macrophage polarizationSemantic proximity Read ↗

Defined Surface Physicochemical Cues Inhibit M1 Polarization of Human Macrophages Using Colloidal Self-Assembled Patterns.Semantic proximity Read ↗

Advances and Challenges in Cryogel-Based Tissue Engineering for Effective Bone and Cartilage ReconstructionSemantic proximity Read ↗

The impact of biomaterial characteristics on macrophage phenotypes in tissue engineering: a reviewSemantic proximity Read ↗

Magnetic nanocomplexes coupled with an external magnetic field modulate macrophage phenotype – a non-invasive strategy for bone regenerationSemantic proximity Read ↗

The effect of chemically modified alginates on macrophage phenotype and biomolecule transport.Semantic proximity Read ↗

Mineralized collagen scaffold pore architecture and glycosaminoglycan content biases anti-inflammatory macrophage phenotypeSemantic proximity Read ↗

Remotely Temporal Scheduled Macrophage Phenotypic Transition Enables Optimized Immunomodulatory Bone Regeneration.Semantic proximity Read ↗

The Immobilization of Hyaluronic Acid in 3D Hydrogel Scaffolds Modulates Macrophage PolarizationSemantic proximity Read ↗

Novel 3-D macrophage spheroid model reveals reciprocal regulation of immunomechanical stress and mechano-immunological responseSemantic proximity Read ↗

Substrate curvature influences cytoskeletal rearrangement and modulates macrophage phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.