Article
A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis.
The European respiratory journal - 1 Dec 2017
Miotto Paolo, Tessema Belay, Tagliani Elisa, Chindelevitch Leonid, Starks Angela M, Emerson Claudia, Hanna Debra, Kim Peter S, Liwski Richard, Zignol Matteo, Gilpin Christopher, Niemann Stefan, Denkinger Claudia M, Fleming Joy, Warren Robin M, Crook Derrick, Posey James, Gagneux Sebastien, Hoffner Sven, Rodrigues Camilla, Comas Iñaki, Engelthaler David M, Murray Megan, Alland David, Rigouts Leen, Lange Christoph, Dheda Keertan, Hasan Rumina, Ranganathan Uma Devi K, McNerney Ruth, Ezewudo Matthew, Cirillo Daniela M, Schito Marco, Köser Claudio U, Rodwell Timothy C
Abstract excerpt
A clear understanding of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis is required to accelerate the development of rapid drug susceptibility testing methods based on genetic sequence.Raw genotype-phenotype correlation data were extracted as part of a comprehensive systematic review to develop a standardised analytical approach for interpreting resistance associated mutations for...
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