Role of the first WHO mutation catalogue in the diagnosis of antibiotic resistance in Mycobacterium tuberculosis in the Valencia Region, Spain: a retrospective genomic analysis.

doi:10.1016/S2666-5247(23)00252-5

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Article

Role of the first WHO mutation catalogue in the diagnosis of antibiotic resistance in Mycobacterium tuberculosis in the Valencia Region, Spain: a retrospective genomic analysis.

The Lancet. Microbe - 1 Jan 2024

García-Marín Ana María, Cancino-Muñoz Irving, Torres-Puente Manuela, Villamayor Luis M, Borrás Rafael, Borrás-Máñez María, Bosque Montserrat, Camarena Juan J, Colomer-Roig Ester, Colomina Javier, Escribano Isabel, Esparcia-Rodríguez Oscar, Gil-Brusola Ana, Gimeno Concepción, Gimeno-Gascón Adelina, Gomila-Sard Bárbara, González-Granda Damiana, Gonzalo-Jiménez Nieves, Guna-Serrano María Remedio, López-Hontangas José Luis, Martín-González Coral, Moreno-Muñoz Rosario, Navarro David, Navarro María, Orta Nieves, Pérez Elvira, Prat Josep, Rodríguez Juan Carlos, Ruiz-García María Montserrat, Vanaclocha Hermelinda, González-Candelas Fernando, Furió Victoria, Comas Iñaki

Abstract excerpt

BACKGROUND: In June, 2021, WHO published the most complete catalogue to date of resistance-conferring mutations in Mycobacterium tuberculosis. Here, we aimed to assess the performance of genome-based antimicrobial resistance prediction using the catalogue and its potential for improving diagnostics in a real low-burden setting. METHODS: In this retrospective population-based genomic study M tuberculosis isolates...

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Identifiers

PMID: 38061383
DOI: 10.1016/S2666-5247(23)00252-5
PMCID: PMC10790317

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