Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL-36 signalling enhances a pro-tumorigenic phenotype in colon cancer cells with cancer cell growth restricted by administration of the IL-36R antagonist.

Oncogene - 1 May 2022

Baker Kevin, O'Donnell Charlotte, Bendix Maura, Keogh Samuel, Byrne James, O'Riordain Michael, Neary Peter, Houston Aileen, Brint Elizabeth

Abstract excerpt

The IL-36 cytokines are a recently described subset of the IL-1 family of cytokines, shown to play a role in the pathogenesis of intestinal diseases such as Inflammatory Bowel Disease (IBD). Given the link between IBD and colitis -associated cancer, as well as the involvement of other IL-1 family members in intestinal tumorigenesis, the aim of this work was to investigate whether IL-36 cytokines play a role in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonic Neoplasms

Share to Cytokines

Share to Inflammatory Bowel Diseases

Share to Interleukin-1

Share to Ki-67 Antigen

Source

Open in PubMed Open full text

Identifiers

PMID: 35365751
DOI: 10.1038/s41388-022-02281-2
PMCID: PMC9076531

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL-36 signalling enhances a pro-tumorigenic phenotype in colon cancer cells with cancer cell growth restricted by administration of the IL-36R antagonist.PMID 35365751Read ↗

The complex roles of IL-36 and IL-38 in cancer: friends or foes?Semantic proximity Read ↗

Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/ IL-23 axisSemantic proximity Read ↗

G-CSF and G-CSFR Modulate CD4 and CD8 T Cell Responses to Promote Colon Tumor Growth and Are Potential Therapeutic Targets.Semantic proximity Read ↗

A Potential Role of IL-6/IL-6R in the Development and Management of Colon CancerSemantic proximity Read ↗

IL-36 cytokines in inflammatory and malignant diseases: not the new kid on the block anymoreSemantic proximity Read ↗

Blockade of IL-6 inhibits tumor immune evasion and improves anti–PD-1 immunotherapySemantic proximity Read ↗

IL‐36 cytokines and gut immunitySemantic proximity Read ↗

IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells.Semantic proximity Read ↗

Targeting IL-11 signaling in colon cancerSemantic proximity Read ↗

miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathwaySemantic proximity Read ↗

Signaling Molecules: The Pathogenic Role of the IL-6/STAT-3 Trans Signaling Pathway in Intestinal Inflammation and in Colonic CancerSemantic proximity Read ↗

Myeloid p38α signaling promotes intestinal IGF‐1 production and inflammation‐associated tumorigenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.