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Cytomegalovirus immune evasion sets the functional avidity threshold for protection by CD8 T cells

1 Apr 2022

Abstract excerpt

Conflicting hallmarks are attributed to cytomegalovirus (CMV) infections. CMVs are viewed as being master tacticians in "immune evasion" by subverting essentially all pathways of innate and adaptive immunity. On the other hand, CMV disease is undeniably restricted to the immunologically immature or immunocompromised host, whereas an intact immune system prevents virus spread, cytopathogenic tissue infection, and...

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PMID: 35364731
DOI: 10.1007/s00430-022-00733-w

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