Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of non-repetitive linker on in vitro and in vivo properties of an anti-VEGF scFv

31 Mar 2022

Abstract excerpt

Abstract Single chain antibody fragments (scFvs) are favored in diagnostic and therapeutic fields thanks to their small size and the availability of various engineering approaches. Linker between variable heavy (VH) and light (VL) chains of scFv covalently links these domains and it can affect scFv’s bio-physical/chemical properties and in vivo activity. Thus, scFv linker design is important for a successful scFv...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Galectins and Cancer Biology
Share to Glycosylation and Glycoproteins Research
Share to Monoclonal and Polyclonal Antibodies Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35361822
DOI: 10.1038/s41598-022-09324-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of non-repetitive linker on in vitro and in vivo properties of an anti-VEGF scFvPMID 35361822Read ↗

Generic Approach for the Generation of Stable Humanized Single-chain Fv Fragments from Rabbit Monoclonal AntibodiesSemantic proximity Read ↗

Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodiesSemantic proximity Read ↗

Effect of linker length between variable domains of single chain variable fragment antibody against daidzin on its reactivitySemantic proximity Read ↗

LegoBody: facile generation of bispecific and multi-specific antibodiesSemantic proximity Read ↗

In Vivo Applications of Single Chain Fv (Variable Domain) (scFv) FragmentsSemantic proximity Read ↗

Optimal charged mutations in the complementarity-determining regions that prevent domain antibody aggregation are dependent on the antibody scaffold.Semantic proximity Read ↗

Linkers: a synergistic way for chimeric proteinsSemantic proximity Read ↗

Sequence features of variable region determining physicochemical properties and polyreactivity of therapeutic antibodiesSemantic proximity Read ↗

Synthetic libraries of shark vNAR domains with different cysteine numbers within the CDR3Semantic proximity Read ↗

Characterization of scFv-Ig Constructs Generated from the Anti-CD20 mAb 1F5 Using Linker Peptides of Varying LengthsSemantic proximity Read ↗

Solubility and stability engineering of human VH domains.Semantic proximity Read ↗

Discovery and bio‐optimization of human antibody therapeutics using the XenoMouse® transgenic mouse platformSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.