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Cryo-EM structures of staphylococcal IsdB bound to human hemoglobin reveal the process of heme extraction

31 Mar 2022

Abstract excerpt

Iron surface determinant B (IsdB) is a hemoglobin (Hb) receptor essential for hemic iron acquisition by Staphylococcus aureus. Heme transfer to IsdB is possible from oxidized Hb (metHb), but inefficient from Hb either bound to oxygen (oxyHb) or bound to carbon monoxide (HbCO), and encompasses a sequence of structural events that are currently poorly understood. By single-particle cryo-electron microscopy, we...

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PMID: 35357971
DOI: 10.1073/pnas.2116708119

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