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Article

Iron-coordinating tyrosine is a key determinant of NEAT domain heme transfer.

Journal of molecular biology - 28 Oct 2011

Grigg Jason C, Mao Cherry X, Murphy Michael E P

Abstract excerpt

In humans, heme iron is the most abundant iron source, and bacterial pathogens such as Staphylococcus aureus acquire it for growth. IsdB of S. aureus acquires Fe(III)-protoporphyrin IX (heme) from hemoglobin for transfer to IsdC via IsdA. These three cell-wall-anchored Isd (iron-regulated surface determinant) proteins contain conserved NEAT (near iron transport) domains. The purpose of this work was to delineate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21893067
DOI: 10.1016/j.jmb.2011.08.047

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