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Article

Nonparametric bounds in two-sample summary-data Mendelian randomization: Some cautionary tales for practice.

Statistics in medicine - 30 Jun 2022

Trane Ralph Møller, Kang Hyunseung

Abstract excerpt

Recently, in genetic epidemiology, Mendelian randomization (MR) has become a popular approach to estimate causal exposure effects by using single nucleotide polymorphisms from genome-wide association studies (GWAS) as instruments. The most popular type of MR study, a two-sample summary-data MR study, relies on having summary statistics from two independent GWAS and using parametric methods for estimation....

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PMID: 35355302
DOI: 10.1002/sim.9368
PMCID: PMC9314714

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