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Article

The landscape of genetic alterations in ameloblastomas relates to clinical features.

Virchows Archiv : an international journal of pathology - 1 May 2018

Gültekin Sibel Elif, Aziz Reem, Heydt Carina, Sengüven Burcu, Zöller Joachim, Safi Ali Farid, Kreppel Matthias, Buettner Reinhard

Abstract excerpt

Ameloblastoma is a mostly benign, but locally invasive odontogenic tumor eliciting frequent relapses and significant morbidity. Recently, mutually exclusive mutations in BRAF and SMO were identified causing constitutive activation of MAPK and hedgehog signaling pathways. To explore further such clinically relevant genotype-phenotype correlations, we here comprehensively analyzed a large series of ameloblastomas...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29388014
DOI: 10.1007/s00428-018-2305-5
PMCID: PMC5978850

Genes

BRAF
SMO
KRAS
NRAS
CTNNB1
EGFR
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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