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Article

Oncogenic mutations and dysregulated pathways in obesity-associated hepatocellular carcinoma.

Oncogene - 8 Dec 2016

Shen J, Tsoi H, Liang Q, Chu E S H, Liu D, Yu A C-S, Chan T F, Li X, Sung J J Y, Wong V W S, Yu J

Abstract excerpt

Epidemiological studies showed that obesity and its related non-alcoholic fatty liver disease (NAFLD) promote hepatocellular carcinoma (HCC) development. We aimed to uncover the genetic alterations of NAFLD-HCC using whole-exome sequencing. We compared HCC development in genetically obese mice and dietary obese mice with wild-type lean mice fed a normal chow after treatment with diethylnitrosamine. HCC tumor and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27132506
DOI: 10.1038/onc.2016.162
PMCID: PMC5153568

Genes

PDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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