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Article

Dysfunction of S100A4 + effector memory CD8 + T cells aggravates asthma

27 Mar 2022

Abstract excerpt

Abstract Progressive loss of effector functions, especially IFN‐γ secreting capability, in effector memory CD8 + T (CD8 + T EM ) cells plays a crucial role in asthma worsening. However, the mechanisms of CD8 + T EM cell dysfunction remain elusive. Here, we report that S100A4 drives CD8 + T EM cell dysfunction, impairing their protective memory response and promoting asthma worsening in an ovalbumin (OVA)‐induced...

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Identifiers

PMID: 35340022
DOI: 10.1002/eji.202149572

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