Article
Allelic variation of the MMP3 promoter affects transcription activity through the transcription factor C-MYB in human brain arteriovenous malformations.
PloS one - 1 Jan 2013
Huai Cong, Song Jianping, Ma Zengyi, Qin Xuanfeng, Li Peiliang, Chen Hongyan, Zhao Fan, Lu Daru, Song Donglei, Mao Ying, Song Xiao, Zhao Yao
Abstract excerpt
MMPs comprise a family of proteolytic enzymes that degrade pericellular substances, which may result in the destabilization of vessels and related to the development of brain arteriovenous malformations (BAVM). MMP3 is a key member of this family, overexpressed in BAVM tissues, and a single nucleotide polymorphism within MMP3, -709A>G (rs522616), is significantly associated with the risk of BAVM. In this study,...
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