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Article

Evaluating genetic variants associated with breast cancer risk in high and moderate-penetrance genes in Asians.

Carcinogenesis - 1 May 2017

Han Mi-Ryung, Zheng Wei, Cai Qiuyin, Gao Yu-Tang, Zheng Ying, Bolla Manjeet K, Michailidou Kyriaki, Dennis Joe, Wang Qin, Dunning Alison M, Brennan Paul, Chen Shou-Tung, Choi Ji-Yeob, Hartman Mikael, Ito Hidemi, Lophatananon Artitaya, Matsuo Keitaro, Miao Hui, Muir Kenneth, Sangrajrang Suleeporn, Shen Chen-Yang, Teo Soo Hwang, Tseng Chiu-Chen, Wu Anna H, Yip Cheng Har, Kang Daehee, Xiang Yong-Bing, Easton Douglas F, Shu Xiao-Ou, Long Jirong

Abstract excerpt

Over the past 20 years, high-penetrance pathogenic mutations in genes BRCA1, BRCA2, TP53, PTEN, STK11 and CDH1 and moderate-penetrance mutations in genes CHEK2, ATM, BRIP1, PALB2, RAD51C, RAD50 and NBN have been identified for breast cancer. In this study, we investigated whether there are additional variants in these 13 genes associated with breast cancer among women of Asian ancestry. We analyzed up to 654...

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Source

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Identifiers

PMID: 28419251
DOI: 10.1093/carcin/bgx010
PMCID: PMC5963497

Genes

BRCA1
BRCA2
CHEK2
PALB2
ATM
BRIP1
CDH1
MAF
NBN
PTEN
RAD50
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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