Article
Association of polymorphisms in microRNA-binding sites and colorectal cancer in an Iranian population.
Cancer genetics - 1 Oct 2012
Azimzadeh Pedram, Romani Sara, Mohebbi Seyed Reza, Mahmoudi Touraj, Vahedi Mohsen, Fatemi Seyed Reza, Zali Narges, Zali Mohammad Reza
Abstract excerpt
MicroRNAs (miRNAs) are agents of post-transcriptional gene expression, and they can affect many functions of an individual cell or tissue from extracellular matrix production to inflammatory processes and tumor development. We aimed to determine the possible role of miRNA-binding site polymorphisms located in five cancer-related genes: IL-16, CDKN2A (p16), RAF1, PTGER4, and ITGB4 in colorectal cancer (CRC) risk...
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