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Article

Visualization of the Effect of Assay Size on the Error Profile of Tumor Mutational Burden Measurement.

Genes - 26 Feb 2022

Bailey Nathanael G

Abstract excerpt

Tumor mutational burden (TMB) refers to the number of somatic mutations in a tumor per megabase and is a biomarker for response to immune checkpoint inhibitor therapy. Immune checkpoint inhibitors are currently approved for tumors with TMB greater than or equal to 10 mutations/megabase. Many laboratories are currently reporting TMB values based upon targeted resequencing panels with limited genomic coverage. Due...

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Identifiers

PMID: 35327986
DOI: 10.3390/genes13030432
PMCID: PMC8949329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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