Article
TMBur: a distributable tumor mutation burden approach for whole genome sequencing.
BMC medical genomics - 7 Sept 2022
Titmuss Emma, Corbett Richard D, Davidson Scott, Abbasi Sanna, Williamson Laura M, Pleasance Erin D, Shlien Adam, Renouf Daniel J, Jones Steven J M, Laskin Janessa, Marra Marco A
Abstract excerpt
BACKGROUND: Tumor mutation burden (TMB) is a key characteristic used in a tumor-type agnostic context to inform the use of immune checkpoint inhibitors (ICI). Accurate and consistent measurement of TMB is crucial as it can significantly impact patient selection for therapy and clinical trials, with a threshold of 10 mutations/Mb commonly used as an inclusion criterion. Studies have shown that the most significant...
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