Article
Multiple system atrophy: the application of genetics in understanding etiology.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society - 1 Feb 2015
Federoff Monica, Schottlaender Lucia V, Houlden Henry, Singleton Andrew
Abstract excerpt
Classically defined phenotypically by a triad of cerebellar ataxia, parkinsonism, and autonomic dysfunction in conjunction with pyramidal signs, multiple system atrophy (MSA) is a rare and progressive neurodegenerative disease affecting an estimated 3-4 per every 100,000 individuals among adults 50-99 years of age. With a pathological hallmark of alpha-synuclein-immunoreactive glial cytoplasmic inclusions (GCIs;...
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