Article
Disruption of anthrax toxin receptor 1 in pigs leads to a rare disease phenotype and protection from senecavirus A infection.
Scientific reports - 23 Mar 2022
Chen Paula R, Rowland Raymond R R, Stoian Ana M, Petrovan Vlad, Sheahan Maureen, Ganta Charan, Cino-Ozuna Giselle, Kim Dae Young, Dunleavey James M, Whitworth Kristin M, Samuel Melissa S, Spate Lee D, Cecil Raissa F, Benne Joshua A, Yan Xingyu, Fang Ying, Croix Brad St, Lechtenberg Kelly, Wells Kevin D, Prather Randall S
Abstract excerpt
Senecavirus A (SVA) is a cause of vesicular disease in pigs, and infection rates are rising within the swine industry. Recently, anthrax toxin receptor 1 (ANTXR1) was revealed as the receptor for SVA in human cells. Herein, the role of ANTXR1 as a receptor for SVA in pigs was investigated by CRISPR/Cas9 genome editing. Strikingly, ANTXR1 knockout (KO) pigs exhibited features consistent with the rare disease, GAPO...
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