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Article

Therapeutic modulation of GSTO activity rescues FUS-associated neurotoxicity via deglutathionylation in ALS disease models.

Developmental cell - 28 Mar 2022

Cha Sun Joo, Lee Seongsoo, Choi Hyun-Jun, Han Yeo Jeong, Jeon Yu-Mi, Jo Myungjin, Lee Shinrye, Nahm Minyeop, Lim Su Min, Kim Seung Hyun, Kim Hyung-Jun, Kim Kiyoung

Abstract excerpt

Fused in sarcoma (FUS) is a DNA/RNA-binding protein that is involved in DNA repair and RNA processing. FUS is associated with neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, the molecular mechanisms underlying FUS-mediated neurodegeneration are largely unknown. Here, using a Drosophila model, we showed that the overexpression of glutathione...

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PMID: 35320731
DOI: 10.1016/j.devcel.2022.02.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Therapeutic modulation of GSTO activity rescues FUS-associated neurotoxicity via deglutathionylation in ALS disease models.PMID 35320731Read ↗

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Yeast as a Model to Unravel Mechanisms Behind FUS Toxicity in Amyotrophic Lateral SclerosisSemantic proximity Read ↗

RNA Binding Protein TAF15 Suppresses Toxicity in a Yeast Model of FUS ProteinopathySemantic proximity Read ↗

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Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.Semantic proximity Read ↗

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Potential Therapeutic Role of HDAC Inhibitors in FUS-ALSSemantic proximity Read ↗

Protein disulphide isomerase (PDI) is protective against amyotrophic lateral sclerosis (ALS)-related mutant Fused in Sarcoma (FUS) in in vitro models.Semantic proximity Read ↗

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