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Article

Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling

11 Jan 2019

Abstract excerpt

Positive-sense RNA viruses hijack intracellular membranes that provide niches for viral RNA synthesis and a platform for interactions with host proteins. However, little is known about host factors at the interface between replicase complexes and the host cytoplasm. We engineered a biotin ligase into a coronaviral replication/transcription complex (RTC) and identified >500 host proteins constituting the RTC...

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PMID: 30632963
DOI: 10.7554/elife.42037

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