Article

Aberrant host mRNA partitioning in Ebola virus condensates driven by RNA folding perpetuates species-dependent interferon response

2025-09-14

Abstract excerpt

RNA viruses form membraneless condensates in host cells to drive replication, but whether these compartments also regulate host RNAs remains unclear. Using MERFISH-based subcellular transcriptomics, we quantified cellular mRNA recruitment into Ebola virus condensates under basal and IFN-stimulated states. We find that in the basal state, cellular RNAs with minimally folded coding regions are selectively recruited....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 38af9099-e638-568a-99e1-3ff54f11020b
DOI: 10.1101/2025.09.13.676059

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aberrant host mRNA partitioning in Ebola virus condensates driven by RNA folding perpetuates species-dependent interferon responseDOI 10.1101/2025.09.13.676059Read

Functional interactomes of the Ebola virus polymerase identified by proximity proteomics in the context of viral replicationSemantic proximity Read

The interface between coronaviruses and host cell RNA biology: Novel potential insights for future therapeutic interventionSemantic proximity Read

RNase L-induced bodies sequester subgenomic flavivirus RNAs to promote viral RNA decaySemantic proximity Read

Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host DynamicsSemantic proximity Read

Phase Separation of a Novel form of Euchromatic Histone Methyltransferasel (EHMT1 <sup>N/C</sup> ) into cytoplasmic RNA viral Inclusion bodies facilitates their coalescence, thereby enhancing viral replicationSemantic proximity Read

P-BODY AND CYTOSKELETON REMODELING BY ORTHOHANTAVIRUSESSemantic proximity Read

Single-cell transcriptional dynamics of flavivirus infectionSemantic proximity Read

RNA-GPS Predicts SARS-CoV-2 RNA Residency to Host Mitochondria and NucleolusSemantic proximity Read

The human DEAD-box protein DDX3X regulates host and viral mRNA translation during Sendai Virus infectionSemantic proximity Read

Dengue Virus Selectively Annexes Endoplasmic Reticulum-Associated Translation Machinery as a Strategy for Co-opting Host Cell Protein SynthesisSemantic proximity Read

A little less aggregation a little more replication: Viral manipulation of stress granulesSemantic proximity Read

Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in dsRNA ResponseSemantic proximity Read