Article
A vasculature niche orchestrates stromal cell phenotype through PDGF signaling: Importance in human fibrotic disease.
Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 2022
Layton Thomas B, Williams Lynn, Yang Nan, Zhang Mingjun, Lee Carl, Feldmann Marc, Trujillo Glenda, Furniss Dominic, Nanchahal Jagdeep
Abstract excerpt
SignificanceTissue fibrotic diseases, for example of the liver and lung, represent a huge unmet medical need. In this study, using single-cell RNA sequencing, cytometry by time of flight (CyTOF), tissue imaging, and functional assays, we identify a complex vascular niche in Dupuytren's disease (DD), a common localized fibrotic condition of the palm, where early-disease-stage tissue can be accessed readily. We...
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