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Article

Antioxidant Responses are Crucial for Defense against Misfolded Human Z-Type α1-Antitrypsin.

Protein and peptide letters - 1 Jan 2022

Im Hana, Lim Jaeyeon

Abstract excerpt

BACKGROUND: The Z-type variant of human α1-antitrypsin is involved in liver cirrhosis and pulmonary emphysema. Due to its slow folding characteristics, this variant accumulates folding intermediates and forms protein aggregates within hepatocytes. Misfolded proteins may induce oxidative stress and subsequent cell death. OBJECTIVE: The potential application of antioxidant response signaling pathway and...

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PMID: 35319354
DOI: 10.2174/0929866529666220321151913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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