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Article

Retarded protein folding of the human Z-type α₁-antitrypsin variant is suppressed by Cpr2p.

Biochemical and biophysical research communications - 28 Feb 2014

Jung Chan-Hun, Kim Yang-Hee, Lee Kyunghee, Im Hana

Abstract excerpt

The human Z-type α1-antitrypsin variant has a strong tendency to accumulate folding intermediates due to extremely slow protein folding within the endoplasmic reticulum (ER) of hepatocytes. Human α1-antitrypsin has 17 peptidyl-prolyl bonds per molecule; thus, the effect of peptidyl-prolyl isomerases on Z-type α1-antitrypsin protein folding was analyzed in this study. The protein level of Cpr2p, a yeast ER...

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PMID: 24502947
DOI: 10.1016/j.bbrc.2014.01.156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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