Article
Hb H disease: clinical course and disease modifiers.
Hematology. American Society of Hematology. Education Program - 1 Jan 2009
Fucharoen Suthat, Viprakasit Vip
Abstract excerpt
Hemoglobin H (Hb H) disease is the most common form of thalassemia intermedia and has many features that require careful consideration in management. In the majority of cases, Hb H disease results from double heterozygosity for alpha(0)-thalassemia due to deletions that remove both linked alpha-globin genes on chromosome 16, and deletional alpha(+)-thalassemia from single alpha-globin gene deletions (--/-alpha)....
Topics
- Folic Acid
- Genetic Heterogeneity
- Hemoglobins, Abnormal
- Humans
- Infant, Newborn
- Phenotype
- Sequence Deletion
- Splenectomy
- alpha-Globins
- alpha-Thalassemia
