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Article

Rare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes.

Nature communications - 12 Jul 2024

Olfson Emily, Farhat Luis C, Liu Wenzhong, Vitulano Lawrence A, Zai Gwyneth, Lima Monicke O, Parent Justin, Polanczyk Guilherme V, Cappi Carolina, Kennedy James L, Fernandez Thomas V

Abstract excerpt

Research demonstrates the important role of genetic factors in attention-deficit/hyperactivity disorder (ADHD). DNA sequencing of families provides a powerful approach for identifying de novo (spontaneous) variants, leading to the discovery of hundreds of clinically informative risk genes for other childhood neurodevelopmental disorders. This approach has yet to be extensively leveraged in ADHD. We conduct...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38997333
DOI: 10.1038/s41467-024-50247-7
PMCID: PMC11245598

Genes

KDM5B

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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